2008 ASBMT Online Seminar
Claudio Anasetti, MD and Benjamin Djulbegovic, MD
Moffitt Cancer Center
University of South Florida
Objectives: This presentation from the Moffitt Cancer Center, University of South Florida, compares stem cell sources from bone marrow versus peripheral blood. Dr. Anasetti reviews well-recognized data that show higher doses of CD34 cells protect against mortality. This information led Dr. Djulbegovic and collaborators to evaluate several published studies (total patients=1100) and report a meta-analysis to determine which product is better for a particular disease and for what reasons. He presents considerable significant detail. The conclusion is peripheral blood and bone marrow produce different products; the choice for a patient should be individualized, based on the ultimate goals of survival and quality of life.